Parkinson's Disease - Global Drug Forecast and Market Analysis to 2022

Parkinson's Disease - Global Drug Forecast and Market Analysis to 2022
New Report Finds Pipeline Agents Aim to Address Unmet Needs of Advanced Patients in Limiting OFF Time
 
Most of the late-stage pipeline agents are set to meet the needs of advanced patients, with five agents expected to launch during the forecast period (Rytary, CVT-301, opicapone, safinamide, and tozadenant); three of them will be used almost exclusively in advanced patients (CVT-301, opicapone, tozadenant). Additional launches of currently marketed drugs in specific markets will include Duodopa in the US and Japan; Neupro in the US, Japan, and Brazil; Nouriast in the US, 5EU, and Japan; Apokyn in Japan; and Requip XL in Japan. GlobalData believes that Newron's safinamide, Impax's Rytary for early and advanced patients and Civitas' CVT-301 for advanced patients are most promising.
 
 
Parkinson's Drug Market till 2022
 
Newron and Zambon’s dual-mechanism MAO-B and glutamate release inhibitor, safinamide, is expected to be a strong competitor in the Parkinson's disease market for early and advanced-stage Parkinson's disease patients, with forecast global sales of $423.2m in 2022. Safinamide is likely to be prescribed over MAO-B inhibitor Azilect (Teva/Lundbeck), due to novel activity as a glutamate release inhibitor. 
 
Impax's Rytary is a slow-release formulation of levodopa that has shown good efficacy and improvements in QOL during clinical trials. Impax is currently finalizing regulatory issues and seeking a new partner for Rytary's ongoing clinical development. In all, the pipeline candidate is forecast to generate sales of $205.3m by 2022, following a late 2014 launch in the US. 
 
Civitas' CVT-301 is a novel reformulation of levodopa and the first inhaled device for Parkinson's disease. It is expected to be the first widely used emergency therapy to meet a key unmet need in wearing-off. Forecast to garner strong sales of $460.1m in 2022, Civitas will likely require partnership for the marketing and sales of its product. 
 
UCB/Biotie's tozadenant is expected to be the second-to-market A2A antagonist that will be used to treat advanced patients, despite limited efficacy in Phase II trials. As a strong player in the Parkinson's disease market, owing to UCB's longstanding presence in the US market and extensive portfolio for Parkinson's disease, tozadenant is forecast to generate global sales of $29.9m in 2022. 
 
 

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