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World's Top Selling Pharmaceutical Drugs and Manufacturers by Sales

World's Top Selling Pharmaceutical Drugs and Manufacturers by Sales

As per the latest data compiled, the top selling pharmaceutical drugs are HUMIRA® (sales USD 19.93 biilion) by AbbVie Inc.,  REVLIMID® (sales USD 9.68 biilion) by Celgene and KEYTRUDA® (sales USD 7.17 biilion) by Merck & Co., Inc..

1.AbbVie Inc.

AbbVie's portfolio of products includes a diversified therapy that address some of the world's most complex and serious diseases. AbbVie's top 3 products for FY 2018 are HUMIRA®, IMBRUVICA® and MAVYRET™; contributes together USD 26.964 billion which is 82.33% of total AbbVie's revenue for FY 2018.


HUMIRA® (adalimumab) is a biologic therapy administered as a subcutaneous injection. It is used to treat the autoimmune diseases such as Adult Crohn's disease, Ankylosing spondylitis, Rheumatoid arthritis, Psoriatic arthritis, Axial spondyloarthropathy and others. Currently It is approved in the United States, Canada and Mexico (collectively, North America) and in the European Union. HUMIRA® is also approved in Japan for the treatment of intestinal Behçet's disease. FY 2018 revenue from HUMIRA® was USD 19.93 billion.

MAVYRET™ (glecaprevir and pibrentasvir) tablets are a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C virus (hep C) genotypes 1, 2, 3, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis. Global MAVYRET sales increased by more than 100% in 2018 as a result of market share gains following the FDA and EMA approvals of MAVYRET in the second half of 2017 as well as further geographic expansion in 2018. FY 2018 revenue from MAVYRET™ was USD 3.59 billion.

IMBRUVICA® (ibrutinib) is an oral, once-daily therapy that inhibits a protein called Bruton's tyrosine kinase (BTK). IMBRUVICA® was one of the first medicines to receive a United States Food and Drug Administration (FDA) approval after being granted a Breakthrough Therapy Designation and is one of the few therapies to receive four separate designations. IMBRUVICA® currently is approved for the treatment of adult patients with diseases such as Chronic lymphocytic leukemia, Mantle cell lymphoma, Waldenström’s macroglobulinemia, Marginal zone lymphoma (MZL) and Chronic graft versus host disease (cGVHD). FY 2018 worldwide revenue from IMBRUVICA® was USD 3.43 billion.

2.Roche Holding AG:

Roche’s sales in the Pharmaceuticals Division increased 7% to USD 43.12 billion; new medicines contributed almost all growth.  Roche’s top 3 products for FY 2018 are Herceptin®, Avastin® and RITUXAN®/MabThera®; contributes together USD 18.642 billion which is 31.98% of total Roche’s revenue for FY 2018.



Herceptin® (Trastuzumab) is the most popular breast cancer medicine that has helped millions of women around the world. Herceptin is approved for the treatment of early-stage breast cancer that is Human Epidermal growth factor Receptor 2-positive (HER2+). Herceptin® is also approved for the treatment of HER2-positive metastatic cancer of the stomach or gastroesophageal junction. Herceptin sales increases (+1%) were mainly driven by growth in the US and in China. In Europe (-16%) and Japan (-16%), sales were affected by biosimilars. FY 2018 revenue from Herceptin® was USD 6.84 billion.

Avastin® (Bevacizumab) is approved for advanced colorectal, breast, lung, kidney, cervical and ovarian cancer and relapsed glioblastoma (a type of brain tumour). Sales increased in the International region (+12%), in the US (+1%) and in Japan (+3%) but declined in Europe (-1%). FY 2018 revenue from Avastin® was USD 6.71 billion.

RITUXAN®/MabThera® (Rituximab) is approved for forms of blood cancer, rheumatoid arthritis and certain types of vasculitis. Sales development was impacted in Europe (-47%) and Japan (-36%) by biosimilar competition. In the Europe, Asia Pacific and other parts of world Rituxan is marketed as MabThera. While in the United States, Japan and Canada MabThera is marketed as Rituxan. FY 2018 revenue from RITUXAN®/MabThera® was USD 5.08 billion.

3.Merck & Co., Inc:

Merck's Pharmaceutical segment includes human health pharmaceutical and vaccine products. Human health pharmaceutical products consist of therapeutic and preventive agents, generally sold by prescription, for the treatment of human disorders. Merck's top 3 products for FY 2018 are KEYTRUDA®, JANUVIA® and GARDASIL®9; contributes together USD 16.236 billion which is 38.39% of total Merck's revenue for FY 2018.

KEYTRUDA® (pembrolizumab), Merck's Oncology division's anti-PD-1 (programmed death receptor-1) therapy, as monotherapy for the treatment of certain patients with non-small-cell lung cancer (NSCLC), melanoma, classical Hodgkin Lymphoma (cHL), urothelial carcinoma, head and neck squamous cell carcinoma (HNSCC), gastric orgastroesophageal junction adenocarcinoma, and microsatellite instability-high (MSI-H) or mismatch repair deficient cancer, and in combination with chemotherapy in certain patients with NSCLC. FY 2018 revenue from KEYTRUDA® was USD 7.17 billion.

JANUVIA® (sitagliptin) and Janumet (sitagliptin/metformin HCl) for the treatment of type 2 diabetes. Worldwide combined sales of Januvia and Janumet, medicines that help lower blood sugar levels in adults with type 2 diabetes, were USD 5.9 billion in 2018, essentially flat compared with 2017.

GARDASIL®9 (Human Papillomavirus 9-valent Vaccine, Recombinant) helps protect girls and women ages 9 to 26 against cervical, vaginal, vulvar, and anal cancers and genital warts caused by 9 types of HPV (human papillomavirus). FY 2018 revenue from GARDASIL®9 was USD 3.15 billion.

4.Bristol-Myers Squibb Company (BMS):

In 2018, BMS revenues increased 9% as a result of higher demand for our prioritized brands including OPDIVO® and ELIQUIS® partially balanced out by increased competition for established brands, primarily HIV brands and Daklinza . BMS top 3 products for FY 2018 are OPDIVO®, ELIQUIS® and ORENCIA®; contributes together USD 15.87 billion which is 70.35% of total BMS revenue for FY 2018.

OPDIVO® (nivolumab), a biological product, is a fully human monoclonal antibody that binds to the PD-1 on T and NKT cells. OPDIVO® is a prescription medicine used to treat people with a type of advanced stage lung cancer (called non-small cell lung cancer). OPDIVO® is also approved for several anti-cancer indications including bladder, blood, colon, head and neck, kidney, liver, lung, melanoma and stomach. The Opdivo + Yervoy regimen also is approved in multiple markets for the treatment of melanoma, RCC, and CRC. FY 2018 revenue from OPDIVO® was USD 6.73 billion.

ELIQUIS® (apixaban) is an oral Factor Xa inhibitor (a class of anticoagulant drugs), targeted at stroke prevention in adult patients with NVAF and the prevention and treatment of VTE disorders. ELIQUIS® is jointly developed and is commercialized by Pfizer and BMSFY 2018 revenue from ELIQUIS® was USD 6.43 billion.

ORENCIA® (abatacept) is a prescription medicine that reduces signs and symptoms in adults with moderate to severe RA (Rheumatoid Arthritis) and Juvenile idiopathic arthritis (JIA). BMS has got approval in Japan for an intravenously administered treatment of moderate to severe polyarticular JIA in patients two years of age and older in Feb 2018. FY 2018 revenue from ORENCIA® was USD 2.71 billion.

5.Pfizer Inc:

Pfizer opeartes in key therapeutic areas included internal medicine, vaccines, oncology, inflammation & immunology, rare disease and consumer healthcare. Pfizer's top 3 products for FY 2018 are PREVNAR 13®, LYRICA® and IBRANCE®; contributes together USD 14.54 billion which is 27.11% of total Pfizer's revenue for FY 2018.

PREVNAR 13® (Pneumococcal 13-valent conjugate vaccine [diphtheria CRM197 protein]) is a vaccine indicated in children 6 weeks through 17 years for active immunization for the prevention of invasive disease caused by Streptococcus pneumoniae serotypes. In adults 18 years of age and older, Prevnar 13® is indicated for active immunization for the prevention of pneumonia and invasive disease caused by Streptococcus pneumoniae serotypes in the vaccine. FY 2018 revenue from PREVNAR 13® was USD 5.80 billion.

LYRICA® (pregabalin) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) to treat fibromyalgia, diabetic nerve pain, spinal cord injury nerve pain and pain after shingles. LYRICA® is also indicated to treat partial onset seizures in adults with epilepsy. The operational growth in worldwide LYRICA® revenues in Innovative Health segment in 2018 was primarily due to growth in the U.S. and growth in the orally dissolving tablet formulation in Japan, partially offset by losses of exclusivity primarily in Australia. FY 2018 revenue from LYRICA® was USD 4.62 billion.

IBRANCE® (palbociclib) is a targeted therapy known as a CDK 4/6 inhibitor. IBRANCE® medication is approved for women with hormone receptor positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer—also known as HR+/HER2-. IBRANCE® maintains class leadership among cyclin-dependent kinase inhibitors in major markets, supported by Pfizer's scientific/clinical data and continued positive patient experience. FY 2018 revenue from IBRANCE® was USD 4.118 billion.

6.Johnson & Johnson:

Johnson & Johnson's Pharmaceutical segment is focused on six therapeutic areas: Immunology (e.g., rheumatoid arthritis, inflammatory bowel disease and psoriasis), Infectious Diseases and Vaccines (e.g., HIV/AIDS), Neuroscience (e.g., mood disorders, neurodegenerative disorders and schizophreni ), Oncology (e.g., prostate cancer and hematologic malignancies), Cardiovascular and Metabolism (e.g., thrombosis and diabetes) and Pulmonary Hypertension (e.g.,Pulmonary Arterial Hypertension). Johnson & Johnson's top 3 products for FY 2018 are REMICADE®, STELARA® and ZYTIGA®; contributes together USD 13.98 billion which is 34.32% of total pharmaceutical revenue for FY 2018.


REMICADE® (infliximab) is marketed by company in the immunology market which is the Company’s largest product. REMICADE® reduces signs and symptoms and induce and maintain remission in adult patients with moderately to severely active Crohn's disease. FY 2018 revenue from REMICADE® was USD 5.32 billion.
STELARA® (ustekinumab) is a prescription medicine approved to treat adults 18 years and older with active psoriatic arthritis, either alone or with methotrexate. Also approved to treat adults 18 years and older with moderately to severely active Crohn’s disease and also used to treat adults and children 12 years and older with moderate or severe plaque psoriasis. STELARA® by sales, is the Company’s 2nd largest product, accounted for approximately 6.3% of the Company's total revenues for fiscal 2018. FY 2018 revenue from STELARA® was USD 5.15 billion.
ZYTIGA® (abiraterone acetate) is a prescription medicine that is used along with prednisone. ZYTIGA® is used to treat men with prostate cancer that has spread to other parts of the body. FY 2018 revenue from ZYTIGA® was USD 3.49 billion.

7.Amgen Inc:

Amgen focuses on innovative human therapeutics including Cardiovascular, Oncology/Hematology, Neuroscience, Inflammation and other areas. Amgen’s top 3 products for FY 2018 are Enbrel®, Neulasta® and Prolia®; contributes together USD 11.77 billion which is 52.31% of total Amgen’s revenue for FY 2018.


Enbrel® (etanercept) is approved for moderately to severely active rheumatoid arthritis; chronic moderate-to-severe plaque psoriasis patients who are candidates for systemic therapy or phototherapy; and active psoriatic arthritis. FY 2018 revenue from Enbrel® was USD 5.01 billion.
Neulasta® (pegfilgrastim) is used primarily in the indication to help reduce the chance of infection due to a low white blood cell count, in patients with certain types of cancer (nonmyeloid) who receive anticancer medicines (chemotherapy) that can cause fever and a low blood cell count. FY 2018 revenue from Neulasta® was USD 4.47 billion.
Prolia® (denosumab) is used primarily in the indication for the treatment of postmenopausal women with osteoporosis at high risk of fracture, defined as a history of osteoporotic fracture, or multiple risk factors for fracture; or patients who have failed or are intolerant to other available osteoporosis therapy. FY 2018 revenue from Prolia® was USD 2.29 billion.

8.Gilead Sciences Inc:

Gilead’s primary areas of focus include HIV/AIDS, liver diseases, hematology/oncology and inflammation/respiratory diseases. Gilead’s top 3 products for FY 2018 are GENVOYA®, TRUVADA® and EPCLUSA®; contributes together USD 9.58 billion which is 43.29% of total Gilead’s revenue for FY 2018.


GENVOYA® (Tenofovir alafenamide) is an oral formulation dosed once a day for the treatment of HIV-1 infection in certain patients. FY 2018 revenue from GENVOYA® was USD 4.62 billion.
TRUVADA (emtricitabine/tenofovir disoproxil fumarate) for PrEP® is an oral formulation indicated in combination with other antiretroviral agents for the treatment of HIV infection and chronic hepatitis B (HCB). FY 2018 revenue from TRUVADA® was USD 2.99 billion.
EPCLUSA® (Sofosbuvir/velpatasvir) is an oral formulation of a once-daily single tablet regimen of sofosbuvir and velpatasvir for the treatment of chronic hepatitis C (HCV) infection in adults with genotype 1, 2, 3, 4, 5 or 6. FY 2018 revenue from EPCLUSA® was USD 1.96 billion.

9.GlaxoSmithKline plc (GSK):

GSK's Pharmaceuticals business has a broad portfolio of innovative and established medicines, with leadership positions in respiratory and HIV. GSK’s top 3 products for FY 2018 are Triumeq®, Seretide®/ Advair® and Tivicay®; contributes together USD 8.92 billion which is 21.76% of total GSK's revenue for FY 2018.


Triumeq® (dolutegravir/abacavir/lamivudine) combines an integrase inhibitor and two nucleoside reverse transcriptase inhibitors to treat HIV infection. Triumeq® was approved by the US Food and Drug Administration (FDA) on 22 August 2014 for the treatment of HIV-1 in adults. FY 2018 revenue from Triumeq® was USD 3.52 billion.
Seretide®/ Advair® (Fluticasone propionate / Salmeterol) is approved to treat asthma and chronic obstructive pulmonary disease (COPD). It is used by breathing the medication into the lungs. FY 2018 revenue from Seretide®/ Advair® was USD 3.22 billion.
Tivicay® (Dolutegravir) is an antiretroviral medication used, together with antiretroviral (ARV) medicines for the treatment of HIV infection. Tivicay has been extensively studied in five phase III clinical trials involving over 3,000 adult people living with HIV. FY 2018 revenue from Tivicay® was USD 2.18 billion.

10.Novartis AG:

Novartis has operates business in three segments – innovative medicines, Sandoz and Alcon. Novartis's top 3 products for FY 2018 are GILENYA™, COSENTYX® and LUCENTIS®; contributes together USD 8.22 billion which is 15.84% of total Novartis revenue for FY 2018.


GILENYA™ (Fingolimod) is an immunomodulating drug, mostly used for treating multiple sclerosis (MS). GILENYA™ is an oral treatment for relapsing-remitting MS, received additional approval in the US and EU in 2018 as the first disease-modifying therapy for young patients with the disease. FY 2018 revenue from GILENYA™ was USD 3.34 billion.

COSENTYX® (Secukinumab) is approved for treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. FY 2018 revenue from COSENTYX® was USD 2.83 billion.

LUCENTIS® (Ranibizumab) has been approved to treat the "wet" type of age-related macular degeneration (AMD, also ARMD), a common form of age-related vision loss. FY 2018 revenue from LUCENTIS® was USD 2.04 billion.

DISCLAIMER: Please be aware that, this analysis is meant for marketing and market research purpose only and should not be treated as medical advice.

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